(308) Oxytocin Troches as an Adjunctive Intervention to Conventional Testosterone and Erectile Dysfunction Medication for Men with Sexuality Concerns

Abstract Introduction Oxytocin (OT), a peptide hormone, is known to be involved in social interaction and the pleasure we derive from it produced posterior pituitary. This neurotransmitter has potential role love, female reproductive functions, bonding. OT released by both males females, during skin contact sexual arousal orgasm/ejaculation (1,2). effects on brain are dependent its interactions with sex homes such as estrogen, progesterone, testosterone, corticosterone. levels implicated male responsivity. biological may include decrease anxiety, increased pair bonding, intimacy closeness enhance receptivity, perineal contractility, enhances nurturing, trust “cuddle intensity of orgasm men women, decreased latency orgasmic release, pleasurable sensations desire lubrication. troches have been used an off label investigational compounded oxytocin adjunctive therapy for men’s health. Objective We report preliminary responder analysis results random retrospective survey users this medication. Methods A convenience sample 26 5 centers ( Hawaii, Washington, Portland, Salt Lake City Tulsa) who tried were surveyed. Surveys anonymous, participation was voluntary uncompensated. Doses Sublingual titrate up 25 international units (IU) optimization, but not exceed 100 IU) Results Fourteen out participants (56%) considered responders. Mean age 43 range 22-77. Eighty-six had between 50 IU 50% TRT replacement whereas 57% Erectile medications. Only 21% ED medications replacement. 86% responders reported enhanced connection their partners, 100% would recommend product friends. 93% planned continue noted overall satisfaction. improved quality orgasm. There no adverse events reported. Responders positive feedback which included: longer lasting before nipple sensation, control premature ejaculation, feelings climax ejaculate volume. Conclusions appear helpful addition preexisting treatment paradigm erectile difficulty or testosterone small numbers, further larger randomized clinical trials warranted planned. Disclosure No